Pre-implantation Genetic Testing

Pre-implantation genetic testing is used to determine chromosomal and genetic problems in embryos from in vitro fertilation (IVF). By screening embryos prior to the time they’re transferred to the uterus couples are able to take a more informed decision on the next steps of the IVF process pgs in Tampa.

PGS – Chromosome Screening

The fertilized eggs and sperm in an IVF cycle have chromosomally unusual features. This occurs the case when there are additional or missing chromosomes. In some cases, these embryos can result in a pregnancy failure or a miscarriage. In some instances embryos may not be viable.

Age, fertility history , and other factors can influence the percentage of chromosomally normal embryos during IVF cycles. If a woman has an increased number of chromosomally defective embryos during the course of her IVF cycle is at a greater risk of having a failed pregnancy.

Using this technology that we have developed, we can analyze the 24 chromosomes of an embryo fertilized in vitro to detect de novo chromosomal irregularities like deletions and additions. The biopsy is utilized to remove some or all of the cells that are in an embryo in vitro. Next-generation sequencing (NGS) can be used to analyze cells for signs of aneuploidy or abnormal chromosomal state.

If the embryo in vitro is affected by a de novo chromosomal abnormality, we will choose these embryos to transfer to the uterus and do not transfer any other embryos that have the same chromosomal problem. This reduces the chance of a failed pregnancy and improve the chance of conception.

PGD – Genetic Diagnosis

We check for genetic diseases in embryos by examining their 24 chromosomes. We also check the genetic information that is found in tiny amounts of the embryo’s trophectoderm cells. The cell-based screening technique has become more popular in recent years and can be used to detect a wide range of genetic diseases in embryos.

This genetic diagnosis is possible in several ways. Generally, we use either a polymerase chain reactions (PCR) or an in situ hybridization (FISH) method. The PCR method is commonly used to identify monogenic disorders and the FISH method is commonly employed to detect chromosomal anomalies.

Since this type of genetic testing only requires a single cell sample It can be helpful to determine the sex of the embryo prior to its implantation. Parents who have any history of or want to find out if they are carriers of a particular genetic disorder can benefit from this kind of genetic test.

Carrier Screening

The Carrier Screening test, which is non-invasive and confidential and safe, is used to screen pregnant women for genetic abnormalities. It helps determine if they are likely to have serious health problems for their kids. Physicians and patients can receive an extensive, clear report, which includes the results and complimentary consultation with a board-certified genetic counselor who can aid them in understanding their risks and determine the future steps.

The diagnosis may be difficult to confirm because of the limited number of samples available. It is particularly important to confirm structural changes detected by PGT-S with CVS or amniocentesis.

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